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Ph.D Position at The University of Queensland
Contact: Professor Elizabeth Gillam: email@example.com
Project Title: Development of Nano-scale Biocatalysts from Cytochrome P450 Enzymes Attached to Virus-Like Particles, for Environmentally Friendly Fine Chemical Production
Description: The project will involve the development of reusable, nano-scale biocatalysts for use in fine chemical synthesis. We will use virus-like particles (VLPs) as scaffolds for attaching cytochrome P450 enzymes to create nano-catalysts for diverse applications in green chemistry, including the sustainable production of bioplastics from seed oils. The research is aimed at gaining a fundamental understanding of the way in which P450s can be immobilised in VLPs as well as how such systems can be customised for industrial applications. The research is to be undertaken in collaboration with CSIRO Biocatalysis Group and will run in parallel with several industry-funded collaborations, offering the successful student the opportunity to be involved in frequent interactions with the industry partners.
Preferred Experience: A working knowledge of molecular biology techniques or HPLC/GC-MS analysis of small molecules would be of benefit to someone working on this project. The applicant will demonstrate academic achievement in the field(s) of Biochemistry, Chemistry, Biotechnology, Structural Biology, Synthetic Biology, Molecular Biology or Plant Biology and the potential for scholastic success. Applications will be judged on a competitive basis taking into account the applicant’s previous academic record, publication record, honours and awards, and employment history.
*The successful candidate must commence by Research Quarter 3, 2021. You should apply at least 3 months prior to the research quarter commencement date. International applicants may need to apply much earlier for visa reasons.
CSIRO Postdoctoral Fellowship in Social Science
This is an identified position and candidates must have a knowledge of the cultural issues affecting Aboriginal and Torres Strait Islander peoples.
The position will sit within the CSIRO Synthetic Biology Future Science Platform, delivering a transformational approach to maximizing impact of synthetic biology science in Australia, and catalyse sustainable management of Australia’s biological heritage from an Indigenous Australian perspective. Our science solutions will integrate Indigenous knowledge and perspectives about synthetic biology/gene technology approaches to improve and result in responsible, positive and measurable outcomes for our (Indigenous) stakeholders and customers.
The Fellow will help to achieve our desired future state of being a global leader in transdisciplinary research and help Australia to become a recognized global leader in social and ethical approaches to synthetic biology research, development and industry growth. Equally, this capability will further CSIRO’s commitment to support Aboriginal and Torres Strait Islander peoples to contribute to, benefit from and improve CSIRO responsible science, innovation and research.
I would be most appreciative if you could please share this advertised position within your networks. Please feel free to contact me if you have any questions. Applications close 22nd July 2020.
CSIRO Postdoctoral Fellowship in Optimising Biodegradation of Plastics
Location: Melbourne, VIC, AU
Are you an early career scientist with an interest in enzyme engineering?
Use your science skills to help solve the problem of plastic debris
Join CSIRO and kick start your research career!
CSIRO Early Research Career (CERC) Postdoctoral Fellowships provide opportunities to scientists and engineers who have completed their doctorate and have less than three years of relevant postdoctoral work experience. These fellowships aim to develop the next generation of future leaders of the innovation system.
In this position, you will work with a diverse range of scientists across CSIRO’s Manufacturing, Data61 and Land & Water business units to help address the problem of plastic waste management and pollution of waterways by microplastics. This is a big challenge due to the chemical stability of the polymers, the complexity of the materials and the scattered pollution sources.
Using your molecular biology and experimental design skills, you will investigate biotechnological solutions to these issues through the design and development of novel enzymes capable of degrading plastic materials. You will engineer poly(ethyleneterephthalate) (PET) esterase enzymes to create a pool of novel enzymes for use in a versatile range of applications from large scale industrial biodegradation of PET material to low temperature activity against high-crystalline PET.
Your duties will include:
Carrying out innovative, impactful research of strategic importance to CSIRO that will, where possible, lead to novel and important scientific outcomes.
Designing of PETase enzymes with increased activity, thermal stability and hc-PET substrate specificity.
Developing and testing high throughput activity assays and mutant screening strategies.
Managing, visualising and statistical analysis of complex data.
Interacting productively with a diverse multidisciplinary, multi-institutional team.
Location: Melbourne VIC
Salary: AU$86k – AU$94k plus up to 15.4% superannuation
Tenure: Specified term of 3 years
To be considered you will need:
A doctorate (or will shortly satisfy the requirements of a PhD) in a relevant discipline area, such as biochemistry, biophysics, chemistry, biology or physics. Please note: To beeligible for this role you must have no more than 3 years (or part-time equivalent) of postdoctoral research experience.
Demonstrated capability in enzyme engineering, molecular biology, biophysics and protein characterisation.
Demonstrated experience in experimental design and management, visualisation and statistical analysis of complex data.
Proven ability to foster productive and inclusive interactions with colleagues from diverse backgrounds.
High-level communication skills including the ability to present research outcomes at national and international conferences.
A sound publication record in peer reviewed journals and/or authorship of scientific papers or reports.
For full details about this role please view the Position Description
The successful applicant will be required to obtain and provide a National Police Check or equivalent and be able to commence in late 2020/ early 2021.
Applicants must be Australian/New Zealand citizens, Australian permanent residents or Australian temporary residents currently residing in Australia.Flexible Working Arrangements
We work flexibly at CSIRO, offering a range of options for how, when and where you work. Talk to us about how this role could be flexible for you. Balance
Diversity and Inclusion
We are working hard to recruit diverse people and ensure that all our people feel supported to do their best work and feel empowered to let their ideas flourish. Diversity and Inclusion Strategy
We are committed to the safety and wellbeing of all children and young people.
At CSIRO, Australia’s national science agency, we solve the greatest challenges through innovative science and technology.
Join us and start creating tomorrow today!
How to Apply
Please apply on-line and provide a cover letter and CV that best demonstrate your motivation and ability to meet the requirements of this role.
16th July 2020, 11:00pm AESTApply now »
Imperial College London
Department of Infectious Diseases| Faculty of Medicine
3-year funded PhD position: Engineering synthetic circuits within bacteria to sense and control the gut microbiome.
Hosted by Dr. David Riglar, Section for Structural and Synthetic Biology, Department of Infectious Disease, Imperial College London
Key words: Synthetic Biology, microbiome, gut, disease,
Overview: The microbes that live in our guts, together known as the gut microbiota, are essential for maintaining our health. Changes to the make-up and function of this microbiota have been associated with a wide range of important diseases including inflammatory bowel disease, colorectal cancer, diabetes and neurodevelopmental disorders. Because of the intimate relationship they have with their surroundings, our microbes offer an exciting opportunity to better understand the gut and to diagnose, monitor and treat disease in the clinic.
The project will utilise synthetic biology to develop engineered bacterial circuits to sense and control the mammalian gut microbiome. The Riglar lab uses a combination of synthetic biology, imaging and sequencing based approaches to better understand the function of the gut and its microbiota during health and disease. We use this knowledge to develop innovative technologies, such as living engineered probiotics, to probe and control the gut environment. The position will involve working with rodent animal models.
Complementing our science, the Riglar lab has a strong focus on developing and maintaining our laboratory culture of personal development, rigorous scientific experimentation, collegiality, and our embrace of honesty, self-awareness and constructive feedback throughout all of our pursuits.
Imperial College is a hub for the advancement of synthetic biology and microbiome sciences. The successful student will be positioned to take advantage of the Centre for Synthetic Biology and Innovation and the London BioFoundry, along with the Department’s close ties with clinical scientists across the Faculty of Medicine and researchers in the Life Sciences and Bioengineering departments. The Department provides a well-developed teaching and support network for PhD students, and the research project will be pursued at the vibrant South Kensington Campus in central London.
How to apply: Please send your CV and a covering letter describing why you are suitable for the studentship and interested in the project and lab, along with the details of two referees to Dr David Riglar firstname.lastname@example.org by 28th June 2020.
Student eligibility: The studentship is funded by the Department of Infectious Diseases, Faculty of Medicine for 3 years and covers home/EU tuition fees and a stipend of £18,000 per annum. Writing up fees of £200 for the final/fourth year are also provided.
Applicants must have or expect to gain a First or Upper Second class undergraduate degree in Synthetic Biology, Systems Biology, Molecular Biology, Microbiology or other related field. A Masters Degree is desirable but not essential. Applicants are also required to meet Imperial College’s English language requirements. Please see the following link: https://www.imperial.ac.uk/study/ug/apply/requirements/english/
The project aims to start in October 2020, with some flexibility to start before or after this date depending on candidate circumstances.
References: (1) Riglar et al. 2019. Nature Communications. (2) Naydich et al. 2019. mSystems. (3) Riglar et al. 2018. Nat Rev Microbiol. (4) Riglar et al. 2017. Nat Biotechnol.
Title: Treatment of multi-drug resistant infections using a novel, rapid, and customised synthetic phage therapy platform.
If you’re looking to be the next potential pioneer in phagetherapy, consider applying for a Ph.D. with Karen Weynberg (University of Queensland) & Paul Jaschke (Macquarie University) to work on synthetic biology tools to fight UTI bacteria
Description: Antimicrobial resistance is increasing at an alarming rate globally. Therefore, there is an urgent need to develop alternative, and potentially complementary, therapeutics to combat pathogenic microbes. The use of phage therapeutic methods in a variety of environments is poorly explored. This project aims to explore further the use of phage therapy by establishing an innovative synthetic biology platform to engineer phage therapy candidates within a biofoundry and will leverage the candidate’s skills in one or more of the following areas – microbiology, molecular biology, genetic engineering and laboratory automation. This project will focus on treating multi-drug resistant uropathogenic E. coli (UPEC), which is responsible for one of the most common illnesses – urinary tract infection – and is increasingly associated with antibiotic resistance. Successful outcomes of this project will be peer-reviewed publications in high-impact journals, intellectual property, and the chance to make a positive difference in the lives of people chronically infected by UPEC pathogens.
Preferred requirements: First class Honours/ Masters in a related discipline such as Microbiology, Molecular Biology, Bioengineering, or Virology
*The successful candidate must commence by Research Quarter 2, 2021. You should apply at least 3 months prior to the research quarter commencement date. International applicants may need to apply much earlier for visa reasons.
Synthetic Biology Postdoctoral Research Associate (University of Florida – Horticultural Sciences Dept)
A synthetic biology postdoctoral position is open in Andrew Hanson’s group at University of Florida https://www.adhansonlab.org/
The Hanson Group is applying synthetic biology approaches to engineering plant and microbial metabolism. Their research aims for a utility to agriculture and the bioeconomy.
Ongoing projects include:
– Using directed evolution via the E. coli EvolvR system (PMID:30069054) and the yeast OrthoRep system (PMID:30415839) to build more energy-efficient versions of the thiamin synthesis enzyme THI4 (PMID:30337452)
– Using directed evolution to extend the working lives of enzymes, and so cut the high energy cost of replacing them (PMID: 30670486)
– Developing new-to-nature synthetic metabolic pathways that benefit agriculture and the environment
We collaborate extensively (via joint Federally-funded projects) and publish with groups at UF, in other US institutions, and in Europe. These groups include synthetic biologists, metabolic engineers, computational biochemists, and plant biochemists.
For our publications see https://scholar.google.com/citations?user=NMKoQqEAAAAJ&hl=en&oi=ao
The position involves contributing to lab management, e.g. by overseeing ordering or coordinating the performance of everyday tasks by other lab members.
– Ph.D. degree in biochemistry, microbiology, chemistry, biotechnology, or a related discipline
– Proven organizational, time-management, and communication skills (oral and written)
– Experience with E. coli and preferably also yeast as genetic and metabolic platform organisms
– Strong interest in applying synthetic biology to metabolic engineering
– Strong interest in plants and plant improvement
Starting salary: $47,476/year. Fringe benefits include health insurance.
To Apply: Please send a letter of application, a detailed CV, and names and email addresses of three referees to email@example.com