If you’d like to advertise a position here please email our Communications Officer at thomas.collier@mq.edu.au


PhD student in Synthetic Glycobiology, University of Gothenburg

We are seeking a PhD student to join our new group at the Department of Chemistry and Molecular Biology & the Wallenberg Centre for Molecular and Translational Medicine of the University of Gothenburg, Sweden.

Glycans or complex carbohydrates constitute the capsules of bacteria, fungi, as well as plant cells, and adorn all kinds of other biomolecules such as proteins, lipids, or RNA. The specific glycan sequence that is physically attached to a protein fundamentally alters its properties and capabilities, fine-tuning stability, structure, and function. We recently demonstrated that – using machine learning – this rich information can be leveraged to predict glycan properties and, in turn, characteristics of the organisms exhibiting these glycans, opening up the potential of glycobiology to facilitate a new understanding of biology and enable future biomedical therapies.

In this project, we will use synthetic biology / genetic engineering to understand and modify the role of glycans in biological systems. With a main focus on mammalian cells, this project will entail state-of-the-art genetic engineering methods, including CRISPR/Cas9 gene editing, as well as systems biology methods such as RNA-seq or glycomics. Further, we will leverage the synergy achieved by the glycan-focused bioinformatics and machine learning expertise in our group to achieve predictive modifications of glycans and analyze their effect on biological systems.

We especially value open-minded, innovative, and mission-driven researchers that are willing to learn. Openness to learning computational analyses (or experience in that area) will be seen as a plus.

For more information visit the link below.

https://web103.reachmee.com/ext/I005/1035/jobsite=7&lang=UK&validator=9b89bead79bb7258ad55c8d75228e5b7&job_id=18729


PhD studentship i-Bio PhD programSorbonne Université

The i-Bio initiative, supported by the French Excellence initiative granted to Sorbonne University Alliance, aims at promoting interdisciplinary research projects at the interface between biology and other disciplines. In 2021, the competition-fundedi-Bio PhD program will offer 4 fully funded three-year PhD grants among fifteen selected projects proposals. A PhD studentship is available in the group of Dr. Stéphane Lemaire (Sorbonne Université, CNRS) in collaboration with the group of Dr. Boris Vauzeilles (Univ Paris-Saclay, CNRS). We are looking for a highly motivated PhD candidate a good background in chemical biology and biochemistry and interested by interdisciplinary research at the chemistry/biology interface. Candidates should have, or be studying for a master’s degree or equivalent in biology or chemistry. Studentship starting date: September-October 2021.

Project description

Glutathione (GSH) is a crucial tripeptide (γGlu-Cys-Gly) present in almost all living organisms. GSH can form a disulfide bond on protein cysteines, a redox post-translational modification favored under changing environmental/stress conditions and called S-glutathionylation. This dynamic modification is mainly controlled by glutaredoxins (GRXs) and constitutes a molecular switch with regulatory and signaling roles involved in numerous fundamental processes and in a wide range of human diseases.
The project aims at dissecting glutathione signaling pathways in the unicellular green alga Chlamydomonas reinhardtii using a bioorthogonal chemo-biological strategy. We will employ a multidisciplinary approach combining chemistry, protein engineering, synthetic biology, genetics and cell biology to develop a genetic circuit enabling the biosynthesis of a clickable analog of GSH in a photosynthetic organism. By engineering a Chlamydomonas strain able to synthesize metabolically a clickable analog of GSH, proteins undergoing S-glutathionylation will be efficiently and selectively enriched using Copper(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC) reaction. Combined with quantitative mass spectrometry, this click-chemistry based approach will allow determining the in vivo dynamics of S-glutathionylation in a photosynthetic model organism as well as the specificities of this redox modification in response to physiological stresses. Moreover, in this engineered strain, selective inactivation, using CRISPR-Cas9, of genes coding for the major GRXs will allow to decipher their specific roles. Combining the identity of glutathionylated cysteines experimentally determined by this innovative chemo-biological approach with protein structural analyses will allow a better understanding of the structural determinants governing both glutathionylation and de-glutathionylation processes. Overall, this project will shed light on the importance and the role of glutathionylation in eukaryotes. 
Detailed project available at: http://ibio.sorbonne-universite.fr/wp-content/uploads/2020/12/LEMAIRE_iBIO_PhD_2021.pdf

Candidate Profile
The candidate must be pro-active, team-oriented and interested in the molecular aspects of stress responses in photosynthetic organisms as well as conducting interdisciplinary research. Ideally, the candidate should have a strong background in biochemistry and chemical biology. Good knowledge in redox signaling or plant biology as well as some experience in proteomics, click chemistry or microalgae manipulation would be highly appreciated.

Context

This doctoral project is a collaborative project between the team “Synthetic and Systems Biology of Microalgae” from the Laboratory of Computational and Quantitative Biology (http://www.lcqb.upmc.fr) at Sorbonne Université in Paris center and the team “Probes and Modulators for Biology” from Institut de Chimie des Substances Naturelles at Université Paris-Saclay in Gif-sur-Yvette (https://icsn.cnrs.fr). The work will be carried out in both laboratories.

Supervisors: Dr. Stéphane Lemaire (LCQB), Dr. Christophe Marchand (LCQB), Dr. Boris Vauzeilles (ICSN), Dr. Aurélie Baron (ICSN). 

Procedure to apply
Applications must be submitted online before the 26th of February 2021.
All details can be found at: http://ibio.sorbonne-universite.fr/application-procedure/.
Interested candidates should contact the supervisors by sending an email to stephane.lemaire@sorbonne-universite.fr and christophe.marchand@sorbonne-universite.fr


Synthetic Biology Postdoctoral Research Associate (University of Florida – Horticultural Sciences Dept)

A synthetic biology postdoctoral position is open in Andrew Hanson’s group at University of Florida https://www.adhansonlab.org/

The Hanson group is applying synthetic biology approaches to engineering plant and microbial metabolism. Their research aims for utility to agriculture and the bioeconomy. Ongoing projects include:

-Using directed evolution via the E. coli T7-DIVA and EvolvR systems and the yeast OrthoRep system to build more energy-efficient versions of the thiamin synthesis enzyme THI4

– Using continuous directed evolution to extend the working lives of enzymes, and so cut the high energy cost of replacing them

– Developing new-to-nature synthetic metabolic pathways that benefit agriculture and the environment 

We collaborate extensively (via joint Federally-funded projects) and publish with groups at UF, in other US institutions, and in Europe. These groups include synthetic biologists, metabolic engineers, computational scientists, and plant biochemists. 

For our publications see https://scholar.google.com/citations?user=NMKoQqEAAAAJ&hl=en&oi=ao  

The position involves contributing to lab management, e.g. by overseeing ordering or coordinating performance of everyday tasks by other lab members.  

Requirements 

– PhD degree in biochemistry, microbiology, chemistry, synthetic biology, or a related discipline

– Proven organizational, time-management, and communication skills (oral and written)

– Experience with E. coli and preferably also yeast as genetic and metabolic platform organisms

– Strong interest in applying synthetic biology to metabolic engineering

– An interest in plants and plant improvement is essential but prior experience in plants is not needed

Starting salary:  $47,476/year.  Fringe benefits include health insurance.

To Apply: Please send a letter of application, a detailed CV, and names and email addresses of three referees to adha@ufl.edu


Hong Kong University of Science and Technology

We are conducting a global talent search in Synthetic Biology. HKUST is setting up the city’s first institute of synthetic biology, with the vision to develop technologies and solutions in the era of new bioeconomy to improve human conditions.Noted you are in the field, we will be very grateful if you could alert your students, postdocs and colleagues to this very unique career opportunity. We are looking for candidates applying synthetic biology for fundamental scientific investigation or innovative technology development in thematic applications in biomedicine, health technology, sustainable living, and food. Faculty at all ranks are welcome, and we are particularly interested in recruiting a Director of the Institute!

Apply Synthetic Biology faculty positions at HKUST Now!

If you know a senior faculty who might be interested, discreet inquiries can be made at synbiohire@ust.hk.

Besides, HKUST will open its new Guangzhou campus in September 2022. The new campus plans to recruit 400 regular faculty in the next 4 years in all research areas, in addition to over 160 new regular faculty in our current Hong Kong campus. More about our recruitment can be found at https://gz-faculty-recruitment.hkust.edu.hk/.

Founded in 1991 as the first research university in Hong Kong, HKUST consistently ranks among the top 50 universities in the world and the world’s best young university in Times Higher Education and QS ranking. With a strong focus on innovation, HKUST graduates were ranked 10th worldwide in the Global University Employability Survey 2019 by the New York Times.

Both HKUST and HKUST(GZ) offer very competitive starting salaries (comparable to the US) with generous retirement, medical and other benefits such as sabbatical leave and waterside campus housing. They are also among the most beautiful campuses in the world. 

For any inquiry, please contact us at synbiohire@ust.hk.


Yeast Synthetic Biology Team Leader & Synthetic biology Scientist: Nourish Ingredients


Yeast Synthetic Biology Team Leader, ACT
$98,000 – $140,000 pa + share options + phone Full Time
Science & Technology
, Biotechnology & Genetics


Yeast Synthetic Biology Scientist, ACT
$63,000 – $94,000 pa + share options
Full Time
Science & Technology
, Biotechnology & Genetics

About Nourish

The plant protein food space is exploding but most companies are using boring, unsustainable fats and oils like coconut and palm that just don’t perform well enough. Nourish is plugging that gap by creating products that customers really need and consumers really want. You shouldn’t have to endure the ‘alternative experience’ when you eat ‘alternative foods’!


Open Biofoundry Positions at the NNF Centre for Bio-sustainability – Denmark

1 analytical chemist – to be advertised

3 postdocs in Computational Strain Design (part of design unit) – about to be advertised

 1 postdoc in Metabolic Engineering (part of Design Unit) – about to be advertised

  8 Computational Scientists for Microbial Reconstructions at PhD, Postdoc and senior researcher level – about to be advertised

We will also be looking for a Biofoundry manager to coordinate this large group and manage the substantial resources.

I am reaching out because we are about to launch CFB 2.0 in January and I would really appreciate your help in promoting our new positions. Continuing our tradition for excellence in cell factory engineering, the next iteration will push hard on Big Data generation and analytics. As a result, we have a number of new positions associated with the Biofoundry either already open or about to open. The positions can all be found on https://www.biosustain.dtu.dk/about/job.

Here are some of the positions already or about to be advertised:

·        4 scientists and/or RAs to our DNA foundry:

o   Research Assistant to ground-breaking microbial strain engineering (dtu.dk)

o   Microbial Strain Engineer (dtu.dk)

·        Postdoc and PhD student for our Genome Engineering group

o   Postdocs in Genome Engineering (dtu.dk)

o   PhD scholarship in Genome Engineering (dtu.dk)

·        Postdoc for Streptomyces Strain Engineering (part of Design Unit)


Ph.D Position at The University of Queensland

Contact: Professor Elizabeth Gillam: e.gillam@uq.edu.au

Project Title: Development of Nano-scale Biocatalysts from Cytochrome P450 Enzymes Attached to Virus-Like Particles, for Environmentally Friendly Fine Chemical Production

Description: The project will involve the development of reusable, nano-scale biocatalysts for use in fine chemical synthesis. We will use virus-like particles (VLPs) as scaffolds for attaching cytochrome P450 enzymes to create nano-catalysts for diverse applications in green chemistry, including the sustainable production of bioplastics from seed oils. The research is aimed at gaining a fundamental understanding of the way in which P450s can be immobilised in VLPs as well as how such systems can be customised for industrial applications. The research is to be undertaken in collaboration with CSIRO Biocatalysis Group and will run in parallel with several industry-funded collaborations, offering the successful student the opportunity to be involved in frequent interactions with the industry partners.

Preferred Experience: A working knowledge of molecular biology techniques or HPLC/GC-MS analysis of small molecules would be of benefit to someone working on this project. The applicant will demonstrate academic achievement in the field(s) of Biochemistry, Chemistry, Biotechnology, Structural Biology, Synthetic Biology, Molecular Biology or Plant Biology and the potential for scholastic success. Applications will be judged on a competitive basis taking into account the applicant’s previous academic record, publication record, honours and awards, and employment history.

*The successful candidate must commence by Research Quarter 3, 2021. You should apply at least 3 months prior to the research quarter commencement date. International applicants may need to apply much earlier for visa reasons.


Treatment of multi-drug resistant infections using a novel, rapid, and customised synthetic phage therapy platform.

If you’re looking to be the next potential pioneer in phagetherapy, consider applying for a Ph.D. with Karen Weynberg (University of Queensland) & Paul Jaschke (Macquarie University) to work on synthetic biology tools to fight UTI bacteria

Description: Antimicrobial resistance is increasing at an alarming rate globally. Therefore, there is an urgent need to develop alternative, and potentially complementary, therapeutics to combat pathogenic microbes. The use of phage therapeutic methods in a variety of environments is poorly explored. This project aims to explore further the use of phage therapy by establishing an innovative synthetic biology platform to engineer phage therapy candidates within a biofoundry and will leverage the candidate’s skills in one or more of the following areas – microbiology, molecular biology, genetic engineering and laboratory automation. This project will focus on treating multi-drug resistant uropathogenic E. coli (UPEC), which is responsible for one of the most common illnesses – urinary tract infection – and is increasingly associated with antibiotic resistance. Successful outcomes of this project will be peer-reviewed publications in high-impact journals, intellectual property, and the chance to make a positive difference in the lives of people chronically infected by UPEC pathogens.

Preferred requirements: First class Honours/ Masters in a related discipline such as Microbiology, Molecular Biology, Bioengineering, or Virology

*The successful candidate must commence by Research Quarter 2, 2021. You should apply at least 3 months prior to the research quarter commencement date. International applicants may need to apply much earlier for visa reasons.

Visit for the official advertising page: graduate-school.uq.edu.au/phd-scholarshi